Yingrun Biotech—— Type Ⅳ collagen combines with multiple components to form the basement membrane network

The basement membrane is the key adhesion zone between the basal layer of epidermal keratinocytes and the dermis. Its integrity is of great significance for maintaining the youthfulness of the skin. Type IV collagen is synthesized in the rough endoplasmic reticulum and secreted into the basement membrane through the Golgi apparatus. It plays a pivotal role in the basement membrane. Type IV collagen is tightly bound to a variety of components to build a stable basement membrane network. The triple helical region of type IV collagen forms a tight connection with the G2 domain of nidogenin; at the same time, nidogenin binds to perlecan and laminin. This complex interaction not only ensures the stability and functionality of the basement membrane, but also plays an indispensable role in maintaining the health and youthfulness of the skin.

Yingrun Biotech—— Maintaining the proportion of papillary fibroblasts is an important means of maintaining basement membrane morphology 

Fibroblasts are one of the main cells in the dermis. Skin aging phenomena such as decreased amounts of elastin and collagen, and increased wrinkles are believed to be related to decreased numbers and decreased vitality of fibroblasts. The dermis is divided into the papillary layer and the reticular layer. The papillary layer fibroblast subpopulation is the papillary fibroblast, and the reticular layer fibroblast subpopulation is the reticular fibroblast. The two types of fibroblasts differ in cell morphology, function, and secreted substances, which affect the interaction between fibroblasts and surrounding cells, especially keratinocytes. Skin aging involves a variety of changes, among which papillary fibroblasts are gradually replaced by reticular fibroblasts, which will affect the morphological structure and function of the basement membrane, thereby accelerating skin aging.

Yingrun Biotech—— RSCare Type Ⅳ Recombinant Collagen Protein and Peptide 

RSCare® T4 series products are recombinant humanized type IV collagen and collagen peptides obtained through microbial fermentation, separation and purification. The molecular weight of collagen is distributed between 3000-10000 Da, and the molecular weight of collagen peptide is less than 1000 Da, with good skin affinity and biocompatibility. It directly hits the root cause of aging and promotes apoptosis of senescent cells; neutralizes aging-related secretory phenotypes, regulates the immune microenvironment; increases the proportion of dermal papillary fibroblasts, and restores skin elasticity. It has excellent effects in removing senescent cells and maintaining youthful skin. 

Data presentation 

Inhibits papillary fibroblast senescence Reduces the proportion of β-galactosidase (one of the markers of cell senescence) positive cells, inhibits cell senescence, and increases the proportion of papillary fibroblasts.

Improved skin texture 

After using the sample containing RSCare® T4 for three weeks, the subjects found that their skin was smoother, more delicate and smoother, and wrinkles around the eyes were significantly improved. 

Test site: left cheek 

Test equipment: VISIA 7, 3D viewing mirror, PIMIA software 

Test site: right lower corner of eye 

Test instrument: VISIA 7, PIMIA software 

Yingrun Biotech not only focuses on product research and development and production, but also pays more attention to meeting the actual needs of customers and providing diversified solutions. In terms of customized development of raw materials, Yingrun Biotechnology develops customized active raw materials from the source, uses advanced biotechnology and enzymology platforms, and conducts targeted research and development for different skin problems and application scenarios to meet the diversified specific needs of customers. Yingrun Biotech is committed to becoming a leader in the beauty and health of mankind. 

References： 

[1]Mak K M , Mei R .Basement Membrane Type IV Collagen and Laminin: An Overview of Their Biology and Value as Fibrosis Biomarkers of Liver Disease[J].The Anatomical Record, 2017, 300(8).   

[2]Breitkreutz D, Koxholt I, Thiemann K, Nischt R. Skin basement membrane: the foundation of epidermal integrity--BM functions and diverse roles of bridging molecules nidogen and perlecan. Biomed Res Int. 2013;2013:179784. .  

[3]Breitkreutz D, Mirancea N, Nischt R. Basement membranes in skin: unique matrix structures with diverse functions? Histochem Cell Biol. 2009 Jul;132(1):1-10.  

[4]Roigrosello E , Rousselle P .The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters[J].Biomolecules, 2020, 10(12).