Product Category
Recombinant Humanized Collagen Type Ⅳ RHCol4(A3)Micro
Category：
keywords：
cosmetics ingredients I aesthetics I medical dressing I repair skin barrier I anti-aging I hair follicle regeneration
Product description
Description
Recombinant humanized type IV collagen peptide directly attacks the root cause of aging, promotes apoptosis of aging cells, neutralizes aging-related secretory phenotypes, regulates the immune microenvironment, increases the proportion of dermal papillary fibroblasts, and restores skin elasticity. It has excellent effects in removing aging cells and maintaining youthful skin.
Parameters
| Items | Specifications |
| Expression Host | Escherichia coli or Pichia pastoris |
| Form | Lyophilized powder |
| Color | White to off-white |
| Molecular Mass | 1000Da |
| Type | Native Protein |
| Expression System | Prokaryotic or Eukaryotic expression |
| Collagen Concentration | ≥0.70g/g (the maximum is ≥ 0.95g/g based on concentration and ultrafiltration) |
| pH | 6.0-7.0 |
| Reactivity | Human |
| Diluent Buffer | PBS solution |
| SDS-PAGE | 1000Da, reducing conditions |
| Storage | Store at 2-8 ℃ for up to six month. |
| Store at -20 ℃ or -80 ℃ for up to one year. | |
| (Avoid repeated freeze/thaw cycles) | |
| Package size | 1g, 5g, 10g, 25g, or customized sizes as needed |
| Alternative Names | RSCare recombinant collagen, COL4, TypeIV collagen, collagen 4, humanized collagen, COL4(A3), human collagen, humanized recombinant type IV collagen, Alpha A3 type IV collagen, AlphaA4 (IV) collagen, COL4A Human, Collagen TypeIV, Yingrun recombinant collagen, yingrun human collagen, Human Type IV Collagen Protein, α3 chain collagen, type IV collagen |
Function
● Regulate anti-apoptosis mechanism and remove senescent cells;
● Revitalize papillary fibroblasts and maintain basement membrane morphology;
● Stabilize collagen fiber arrangement and restore skin elasticity.
Application
● The application of recombinant type IV collagen is mainly reflected in its unique biocompatibility and bioactivity, which provides new solutions for medical and beauty fields.
● The application of recombinant type VI collagen is also reflected in its role as a "regulator" of collagen fibers and a "connector" between the dermal matrix and the basement membrane. For example, in skin care products, it can be used as a raw material for skin collagen synthesis, promoting more collagen synthesis, thereby improving skin condition.
FAQ
Q: What is the source of recombinant humanized collagen?
A: Human collagen is synthesized through genetic engineering technology. Recombinant humanized collagen is not extracted from human tissue. Recombinant humanized collagen is based on the original gene sequence of type III collagen in human skin. It is optimized and selected for codon optimization and splicing recombination of the parts with strong water solubility and high biological activity, and scalable production is achieved using biofermentation technology. In other words, the amino acid sequence of recombinant humanized collagen is 100% consistent with human collagen. It is a full-length or partial amino acid sequence fragment encoded by a specific type of human collagen gene prepared by DNA recombination technology, or a combination of functional fragments of human collagen.
Q: In what format are the collagen proteins provided?
A: Collagen proteins are provided in liquid format or Lyophilized powder format at a concentration of around 1 mg/mL or ≥0.70g/g. The collagen proteins are solubilized, maintaining their native structure. No enzymatic treatment is performed. The low pH of the buffer is essential in maintaining the solubility of the collagen protein.
Q: What are the shipping conditions for recombinant proteins?
A: Most recombinant proteins are shipped at blue ice or room temperature. Lyophilization improves product stability and reduces packing materials and shippingcosts. Data from quality control tests indicates that lyophilized products shipped at ambient temperature retain full activity when delivered promptly and stored properly.
Q: How should I handle the products before formulation or use?
A: During transportation, the compounds may adhere to the neck or cap of the vial. Before opening the vial, please centrifuge to gather the compound at the bottom of the vial.
Q: How can I prepare the compound stock solution?
A: Based on the data we provided, If you can not find the solubility information you are looking for, or you are having difficulty preparing a product in solution form, you can also get help via email support@rscarebio.com. Once prepared, aliquot the stock solution to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Q: How can I obtain product Data Sheet, Data files, etc.?
A: A: We automatically send product Data Sheet and data documents to your email after shipment.
B: You can download related files on the product webpage from our website www.rscarebio.com.
C: Also you can request the documents from our customer service by send email.
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